Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.
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ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC6173642 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.
Liu Xiaojing X Cooper Daniel E DE Cluntun Ahmad A AA Warmoes Marc O MO Zhao Steven S Reid Michael A MA Liu Juan J Lund Peder J PJ Lopes Mariana M Garcia Benjamin A BA Wellen Kathryn E KE Kirsch David G DG Locasale Jason W JW
Cell 20180920 2
Acetate is a major nutrient that supports acetyl-coenzyme A (Ac-CoA) metabolism and thus lipogenesis and protein acetylation. However, its source is unclear. Here, we report that pyruvate, the end product of glycolysis and key node in central carbon metabolism, quantitatively generates acetate in mammals. This phenomenon becomes more pronounced in the context of nutritional excess, such as during hyperactive glucose metabolism. Conversion of pyruvate to acetate occurs through two mechanisms: (1) ...[more]
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