Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Romero MA
PROVIDER: S-EPMC6173691 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Sánchez-Romero María Antonia MA Casadesús Josep J
Scientific reports 20181005 1
Salmonella enterica pathogenicity island 1 (SPI-1) is a gene cluster that encodes a type III secretion system and effectors involved in epithelial cell invasion. SPI-1 undergoes bistable expression, with concomitant formation of SPI-1<sup>ON</sup> and SPI-1<sup>OFF</sup> lineages. This study describes single cell analysis of SP1-1 bistability and epithelial cell invasion, and reports the unsuspected observation that optimal invasion of epithelial cells requires the presence of both SPI-1<sup>ON< ...[more]