Splenectomy modulates early immuno-inflammatory responses to trauma-hemorrhage and protects mice against secondary sepsis.
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ABSTRACT:
SUBMITTER: Drechsler S
PROVIDER: S-EPMC6173732 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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Splenectomy modulates early immuno-inflammatory responses to trauma-hemorrhage and protects mice against secondary sepsis.
Drechsler S S Zipperle J J Rademann P P Jafarmadar M M Klotz A A Bahrami S S Osuchowski M F MF
Scientific reports 20181005 1
In polytrauma patients, the impact of splenectomy is equivocal, ranging from negative to protective. We investigated the impact of splenectomy on immune responses in the 1<sup>st</sup>-hit polytrauma alone and on survival in the post-traumatic sepsis (2<sup>nd</sup> hit). Female BALB/c mice underwent polytrauma (1<sup>st</sup> hit) consisting of either a) TH: femur fracture, hemorrhagic shock or b) TSH: splenectomy, femur fracture, hemorrhagic shock. Additionally, the polytrauma hit was followed ...[more]
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