Ontology highlight
ABSTRACT:
SUBMITTER: Komakula SSB
PROVIDER: S-EPMC6173743 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Komakula Sai Santosh Babu SSB Tumova Jana J Kumaraswamy Deeptha D Burchat Natalie N Vartanian Vladimir V Ye Hong H Dobrzyn Agnieszka A Lloyd R Stephen RS Sampath Harini H
Scientific reports 20181005 1
Obesity and related metabolic pathologies represent a significant public health concern. Obesity is associated with increased oxidative stress that damages genomic and mitochondrial DNA. Oxidatively-induced lesions in both DNA pools are repaired via the base-excision repair pathway, initiated by DNA glycosylases such as 8-oxoguanine DNA glycosylase (OGG1). Global deletion of OGG1 and common OGG1 polymorphisms render mice and humans susceptible to metabolic disease. However, the relative contribu ...[more]