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Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores.

ABSTRACT: Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time directly from nanoliter amounts of blood and other bodily fluids. Incorporation of the nanopore into portable electronic devices will allow developing sensitive, continuous, and non-invasive sensors for metabolites for point-of-care and home diagnostics.

SUBMITTER: Galenkamp NS

PROVIDER: S-EPMC6173770 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores.

Galenkamp Nicole Stéphanie NS Soskine Misha M Hermans Jos J Wloka Carsten C Maglia Giovanni G

Nature communications 20181005 1

Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time directly from nanoliter amounts of blood and other bodily fluids. Incorporation of the nanopore into portable electronic devices will allow developing sensitive, continuous, and no ...[more]

PMID: 30291230

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