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An odorant receptor from Anopheles sinensis in China is sensitive to oviposition attractants.


ABSTRACT: BACKGROUND:Anopheles sinensis is an important vector for the spread of malaria in China. Olfactory-related behaviours, particularly oviposition site seeking, offer opportunities for disrupting the disease-transmission process. RESULTS:This is the first report of the identification and characterization of AsinOrco and AsinOR10 in An. sinensis. AsinOrco and AsinOR10 share 97.49% and 90.37% amino acid sequence identity, respectively, with related sequences in Anopheles gambiae. A functional analysis demonstrated that AsinOrco- and AsinOR10-coexpressing HEK293 cells were highly sensitive to 3-methylindole, but showed no significant differences in response to other test odorants when compared to DMSO. CONCLUSIONS:AsinOrco was characterized as a new member of the Orco ortholog subfamily. AsinOR10, which appears to be a member of the OR2-10 subfamily, is directly involved in identification of oviposition sites. This finding will help to elucidate the molecular mechanisms underlying olfactory signaling in An. sinensis and provide many more molecular targets for eco-friendly pest control.

SUBMITTER: Liu H 

PROVIDER: S-EPMC6173891 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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An odorant receptor from Anopheles sinensis in China is sensitive to oviposition attractants.

Liu Hongmei H   Liu Luhong L   Cheng Peng P   Huang Xiaodan X   Gong Maoqing M  

Malaria journal 20181005 1


<h4>Background</h4>Anopheles sinensis is an important vector for the spread of malaria in China. Olfactory-related behaviours, particularly oviposition site seeking, offer opportunities for disrupting the disease-transmission process.<h4>Results</h4>This is the first report of the identification and characterization of AsinOrco and AsinOR10 in An. sinensis. AsinOrco and AsinOR10 share 97.49% and 90.37% amino acid sequence identity, respectively, with related sequences in Anopheles gambiae. A fun  ...[more]

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