POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy.
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ABSTRACT:
SUBMITTER: Restani RB
PROVIDER: S-EPMC6174550 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy.
Restani Rita B RB Pires Rita F RF Tolmatcheva Anna A Cabral Rita R Baptista Pedro V PV Fernandes Alexandra R AR Casimiro Teresa T Bonifácio Vasco D B VDB Aguiar-Ricardo Ana A
ChemistryOpen 20180725 10
POxylated polyurea dendrimer (PURE<sub>G4</sub>OOx<sub>48</sub>)-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO<sub>2</sub>-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma ...[more]
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