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POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy.

ABSTRACT: POxylated polyurea dendrimer (PURE_G4OOx₄₈)-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO₂-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In?vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PURE_G4OOx₄₈ nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX-DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.

SUBMITTER: Restani RB

PROVIDER: S-EPMC6174550 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy.

Restani Rita B RB Pires Rita F RF Tolmatcheva Anna A Cabral Rita R Baptista Pedro V PV Fernandes Alexandra R AR Casimiro Teresa T Bonifácio Vasco D B VDB Aguiar-Ricardo Ana A

ChemistryOpen 20180725 10

POxylated polyurea dendrimer (PUREG4OOx48)-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma ...[more]

PMID: 30338202

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