Ontology highlight
ABSTRACT:
SUBMITTER: Zettergren A
PROVIDER: S-EPMC6175024 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Zettergren Anna A Kern Silke S Rydén Lina L Östling Svante S Blennow Kaj K Zetterberg Henrik H Falk Hanna H Skoog Ingmar I
The journals of gerontology. Series A, Biological sciences and medical sciences 20181001 11
Self-rated health (SRH) strongly predicts mortality. Twin studies estimate that genetic factors account for a substantial part of the variability in SRH. Variations in the gene FOXO3 (forkhead box O3), and in genes located at the APOE (apoplipoprotein E) locus, are associated with longevity. This study explores the relationship between SRH and genetic variation related to longevity, in a population-based cohort of older individuals. SRH was assessed among 1,520 individuals aged 75-87, and five s ...[more]