Ontology highlight
ABSTRACT:
SUBMITTER: Donlon TA
PROVIDER: S-EPMC6175033 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Donlon Timothy A TA Morris Brian J BJ Chen Randi R Masaki Kamal H KH Allsopp Richard C RC Willcox D Craig DC Tiirikainen Maarit M Willcox Bradley J BJ
The journals of gerontology. Series A, Biological sciences and medical sciences 20181001 11
Longevity is a polygenic trait in which genetic predisposition is particularly important. We hypothesized that among genes differentially expressed in response to caloric restriction, several may be candidate longevity genes. We tested 459 single-nucleotide polymorphisms (SNPs) in 47 genes differentially expressed in calorically restricted mice and 12 other genes for association with longevity. Subjects were American men of Japanese ancestry, 440 aged ≥95 years and 374 with an average life span. ...[more]