Ontology highlight
ABSTRACT:
SUBMITTER: Cabukusta B
PROVIDER: S-EPMC6175085 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Cabukusta Birol B Neefjes Jacques J
Traffic (Copenhagen, Denmark) 20180717 10
Lysosomes are highly dynamic organelles that can move rapidly throughout the cell. They distribute in a rather immobile pool located around the microtubule-organizing center in a "cloud," and a highly dynamic pool in the cell periphery. Their spatiotemporal characteristics allow them to carry out multiple biological functions, such as cargo degradation, antigen presentation and plasma membrane repair. Therefore, it is not surprising that lysosomal dysfunction underlies various diseases, includin ...[more]