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Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In?Vivo Field-Cycling Relaxometry.


ABSTRACT: It was established through in?vivo T1 measurements at low magnetic fields that tumour cells display proton T1 values that are markedly longer than those shown by healthy tissue. Moreover, it has been found that the elongation of T1 parallels the aggressiveness of the investigated tumour. The T1 lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na+ /K+ ATPase transporters. It follows that the intracellular water lifetime represents a hallmark of tumour cells that can be easily monitored by measuring T1 at different magnetic field strengths ranging from 0.2 to 200?mT.

SUBMITTER: Ruggiero MR 

PROVIDER: S-EPMC6175164 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field-Cycling Relaxometry.

Ruggiero Maria Rosaria MR   Baroni Simona S   Pezzana Stefania S   Ferrante Gianni G   Geninatti Crich Simonetta S   Aime Silvio S  

Angewandte Chemie (International ed. in English) 20180414 25


It was established through in vivo T<sub>1</sub> measurements at low magnetic fields that tumour cells display proton T<sub>1</sub> values that are markedly longer than those shown by healthy tissue. Moreover, it has been found that the elongation of T<sub>1</sub> parallels the aggressiveness of the investigated tumour. The T<sub>1</sub> lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na<sup>+<  ...[more]

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