Ontology highlight
ABSTRACT:
SUBMITTER: Ruggiero MR
PROVIDER: S-EPMC6175164 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Ruggiero Maria Rosaria MR Baroni Simona S Pezzana Stefania S Ferrante Gianni G Geninatti Crich Simonetta S Aime Silvio S
Angewandte Chemie (International ed. in English) 20180414 25
It was established through in vivo T<sub>1</sub> measurements at low magnetic fields that tumour cells display proton T<sub>1</sub> values that are markedly longer than those shown by healthy tissue. Moreover, it has been found that the elongation of T<sub>1</sub> parallels the aggressiveness of the investigated tumour. The T<sub>1</sub> lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na<sup>+< ...[more]