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Photo-Organocatalytic Enantioselective Radical Cascade Reactions of Unactivated Olefins.

ABSTRACT: Radical cascade processes are invaluable for their ability to rapidly construct complex chiral molecules from simple substrates. However, implementing catalytic asymmetric variants is difficult. Reported herein is a visible-light-mediated organocatalytic strategy that exploits the excited-state reactivity of chiral iminium ions to trigger radical cascade reactions with high enantioselectivity. By combining two sequential radical-based bond-forming events, the method converts unactivated olefins and ?,?-unsaturated aldehydes into chiral adducts in a single step. The implementation of an asymmetric three-component radical cascade further demonstrates the complexity-generating power of this photochemical strategy.

SUBMITTER: Bonilla P

PROVIDER: S-EPMC6175195 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Photo-Organocatalytic Enantioselective Radical Cascade Reactions of Unactivated Olefins.

Bonilla Pablo P Rey Yannick P YP Holden Catherine M CM Melchiorre Paolo P

Angewandte Chemie (International ed. in English) 20180831 39

Radical cascade processes are invaluable for their ability to rapidly construct complex chiral molecules from simple substrates. However, implementing catalytic asymmetric variants is difficult. Reported herein is a visible-light-mediated organocatalytic strategy that exploits the excited-state reactivity of chiral iminium ions to trigger radical cascade reactions with high enantioselectivity. By combining two sequential radical-based bond-forming events, the method converts unactivated olefins ...[more]

PMID: 30098097

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