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A prospective evaluation of plasma polyphenol levels and colon cancer risk.

ABSTRACT: Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (qvalues ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log2 -transformed multivariable models, equol (odds ratio [OR] per log2 -value, 0.86, 95% confidence interval [95% CI]?=?0.79-0.93; qvalue ?=?0.01) and homovanillic acid (OR per log2 -value, 1.46, 95% CI?=?1.16-1.84; qvalue ?=?0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR?=?0.61, 95% CI?=?0.41-0.91, ptrend ?=?0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR?=?1.72, 95% CI?=?1.17-2.53, ptrend ?

SUBMITTER: Murphy N

PROVIDER: S-EPMC6175205 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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A prospective evaluation of plasma polyphenol levels and colon cancer risk.

Murphy Neil N Achaintre David D Zamora-Ros Raul R Jenab Mazda M Boutron-Ruault Marie-Christine MC Carbonnel Franck F Savoye Isabelle I Kaaks Rudolf R Kühn Tilman T Boeing Heiner H Aleksandrova Krasimira K Tjønneland Anne A Kyrø Cecilie C Overvad Kim K Quirós J Ramón JR Sánchez Maria-Jose MJ Altzibar Jone M JM María Huerta José J Barricarte Aurelio A Khaw Kay-Tee KT Bradbury Kathryn E KE Perez-Cornago Aurora A Trichopoulou Antonia A Karakatsani Anna A Peppa Eleni E Palli Domenico D Grioni Sara S Tumino Rosario R Sacerdote Carlotta C Panico Salvatore S Bueno-de-Mesquita H B As HBA Peeters Petra H PH Rutegård Martin M Johansson Ingegerd I Freisling Heinz H Noh Hwayoung H Cross Amanda J AJ Vineis Paolo P Tsilidis Kostas K Gunter Marc J MJ Scalbert Augustin A

International journal of cancer 20180611 7

Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols ...[more]

PMID: 29696648

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Project description:BackgroundAssociations of obesity and obesity-related metabolic factors (adiposity factors) with uterine corpus cancer (UCC) and ovarian cancer (OVC) risk have been described. Still, a cause-effect relationship and the underlying mediators remain unclear, particularly for low-incidence populations. We aimed to prospectively determine whether adiposity factors could predict the development of UCC and OVC in Taiwanese women. To explore the biological mediators linking adiposity factors to cancer risk, we examined the association of two adipokines, leptin and adiponectin, with the gynecological cancers.MethodsTotally, 11,258 women, aged 30-65, were recruited into the Community-Based Cancer Screening Program (CBCSP) study during 1991-1993, and were followed for UCC and OVC cases until December 31, 2011. Cox proportional hazard models were used to estimate hazard ratios (HRs). Adiposity factors and risk covariates were assessed at recruitment. Newly-developed cancer cases were determined from data in the government's National Cancer Registry and Death Certification System. For adipokienes study, a nested case-control study was conducted within the cohort. Baseline plasma samples of 40 incident gynecological cancer cases and 240 age-menopause-matched controls were assayed for adipokines levels.FindingsThere were 38 and 30 incident cases of UCC and OVC, respectively, diagnosed during a median 19.9 years of follow-up. Multivariate analysis showed that alcohol intake (HR = 16.00, 95%? = 4.83-53.00), high triglyceride levels (HR = 2.58, 95%?= 1.28-5.17), and years of endogenous estrogen exposure per 5-year increment (HR = 1.91, 95%? = 1.08-3.38) were associated with increased UCC risk. High body mass index (BMI ? 27 kg/m(2), HR = 2.90, 95% ?= 1.30-6.46) was associated with increased OVC risk. Analysis further showed an independent effect of adipokines on UCC and OVC risk after adjustment of the risk covariates.ConclusionWe provided evidence that alcohol intake, high triglyceride levels and long endogenous estrogen exposure increase UCC risk, whereas obesity positively predicts OVC risk. Circulating adipokines may mediate the link of adiposity factors to gynecological cancer risk.

Dataset Information

A prospective evaluation of plasma polyphenol levels and colon cancer risk.

Publications

A prospective evaluation of plasma polyphenol levels and colon cancer risk.

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