Ontology highlight
ABSTRACT:
SUBMITTER: Yue L
PROVIDER: S-EPMC6175521 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Yue Lei L Pang Zheng Z Li Hua H Yang Ting T Guo Lei L Liu Longding L Mei Junjie J Song Xia X Xie Tianhong T Zhang Ye Y He Xin X Lin Tong-Jun TJ Xie Zhongping Z
PloS one 20181008 10
Platelets have been implicated in pulmonary inflammation following exposure to bacterial stimuli. The mechanisms involved in the platelet-mediated host response to respiratory bacterial infection remain incompletely understood. In this study, we demonstrate that platelet-derived chemokine (C-X-C motif) ligand 4 (CXCL4) plays critical roles in a mouse model of acute bacterial pneumonia using Pseudomonas aeruginosa. Platelets are activated during P. aeruginosa infection, and mice depleted of plate ...[more]