Ontology highlight
ABSTRACT:
SUBMITTER: Sakamoto S
PROVIDER: S-EPMC6175529 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Sakamoto Satoko S Thumkeo Dean D Ohta Hiroshi H Zhang Zhen Z Huang Shuangru S Kanchanawong Pakorn P Fuu Takayoshi T Watanabe Sadanori S Shimada Kentaro K Fujihara Yoshitaka Y Yoshida Shosei S Ikawa Masahito M Watanabe Naoki N Saitou Mitinori M Narumiya Shuh S
PLoS biology 20180926 9
Formin is one of the two major classes of actin binding proteins (ABPs) with nucleation and polymerization activity. However, despite advances in our understanding of its biochemical activity, whether and how formins generate specific architecture of the actin cytoskeleton and function in a physiological context in vivo remain largely obscure. It is also unknown how actin filaments generated by formins interact with other ABPs in the cell. Here, we combine genetic manipulation of formins mammali ...[more]