Ontology highlight
ABSTRACT:
SUBMITTER: Odaka YS
PROVIDER: S-EPMC6175831 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Odaka Yuri S YS Tohmonda Takahide T Toyoda Atsushi A Aruga Jun J
Scientific reports 20181008 1
Zic3 encodes a zinc finger protein essential for the development of meso-ectodermal tissues. In mammals, Zic3 has important roles in the development of neural tube, axial skeletons, left-right body axis, and in maintaining pluripotency of ES cells. Here we characterized cis-regulatory elements required for Zic3 expression. Enhancer activities of human-chicken-conserved noncoding sequences around Zic1 and Zic3 were screened using chick whole-embryo electroporation. We identified enhancers for mes ...[more]