Blood meal-induced inhibition of vector-borne disease by transgenic microbiota.
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ABSTRACT:
SUBMITTER: Shane JL
PROVIDER: S-EPMC6175951 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Blood meal-induced inhibition of vector-borne disease by transgenic microbiota.
Shane Jackie L JL Grogan Christina L CL Cwalina Caroline C Lampe David J DJ
Nature communications 20181008 1
Vector-borne diseases are a substantial portion of the global disease burden; one of the deadliest of these is malaria. Vector control strategies have been hindered by mosquito and pathogen resistances, and population alteration approaches using transgenic mosquitos still have many hurdles to overcome before they can be implemented in the field. Here we report a paratransgenic control strategy in which the microbiota of Anopheles stephensi was engineered to produce an antiplasmodial effector cau ...[more]
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