Ontology highlight
ABSTRACT:
SUBMITTER: Kocaturk NM
PROVIDER: S-EPMC6175981 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Kocaturk Nur Mehpare NM Gozuacik Devrim D
Frontiers in cell and developmental biology 20181002
Autophagy and the ubiquitin-proteasome system (UPS) are the two major intracellular quality control and recycling mechanisms that are responsible for cellular homeostasis in eukaryotes. Ubiquitylation is utilized as a degradation signal by both systems, yet, different mechanisms are in play. The UPS is responsible for the degradation of short-lived proteins and soluble misfolded proteins whereas autophagy eliminates long-lived proteins, insoluble protein aggregates and even whole organelles (e.g ...[more]