Unknown

Dataset Information

0

Anatomical and microstructural determinants of hippocampal subfield functional connectome embedding.


ABSTRACT: The hippocampus plays key roles in cognition and affect and serves as a model system for structure/function studies in animals. So far, its complex anatomy has challenged investigations targeting its substructural organization in humans. State-of-the-art MRI offers the resolution and versatility to identify hippocampal subfields, assess its microstructure, and study topographical principles of its connectivity in vivo. We developed an approach to unfold the human hippocampus and examine spatial variations of intrinsic functional connectivity in a large cohort of healthy adults. In addition to mapping common and unique connections across subfields, we identified two main axes of subregional connectivity transitions. An anterior/posterior gradient followed long-axis landmarks and metaanalytical findings from task-based functional MRI, while a medial/lateral gradient followed hippocampal infolding and correlated with proxies of cortical myelin. Findings were consistent in an independent sample and highly stable across resting-state scans. Our results provide robust evidence for long-axis specialization in the resting human hippocampus and suggest an intriguing interplay between connectivity and microstructure.

SUBMITTER: Vos de Wael R 

PROVIDER: S-EPMC6176604 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Anatomical and microstructural determinants of hippocampal subfield functional connectome embedding.

Vos de Wael Reinder R   Larivière Sara S   Caldairou Benoît B   Hong Seok-Jun SJ   Margulies Daniel S DS   Jefferies Elizabeth E   Bernasconi Andrea A   Smallwood Jonathan J   Bernasconi Neda N   Bernhardt Boris C BC  

Proceedings of the National Academy of Sciences of the United States of America 20180924 40


The hippocampus plays key roles in cognition and affect and serves as a model system for structure/function studies in animals. So far, its complex anatomy has challenged investigations targeting its substructural organization in humans. State-of-the-art MRI offers the resolution and versatility to identify hippocampal subfields, assess its microstructure, and study topographical principles of its connectivity in vivo. We developed an approach to unfold the human hippocampus and examine spatial  ...[more]

Similar Datasets

| S-EPMC5797202 | biostudies-literature
| S-EPMC5524625 | biostudies-literature
| S-EPMC3289761 | biostudies-literature
2020-05-11 | GSE138082 | GEO
| S-EPMC4907820 | biostudies-literature
| S-EPMC9289864 | biostudies-literature
| S-EPMC6010566 | biostudies-literature
| S-EPMC7463163 | biostudies-literature
| S-EPMC6261348 | biostudies-literature
| S-EPMC8170416 | biostudies-literature