Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.
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ABSTRACT:
SUBMITTER: Anderson ND
PROVIDER: S-EPMC6176908 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.
Anderson Nathaniel D ND de Borja Richard R Young Matthew D MD Fuligni Fabio F Rosic Andrej A Roberts Nicola D ND Hajjar Simon S Layeghifard Mehdi M Novokmet Ana A Kowalski Paul E PE Anaka Matthew M Davidson Scott S Zarrei Mehdi M Id Said Badr B Schreiner L Christine LC Marchand Remi R Sitter Joseph J Gokgoz Nalan N Brunga Ledia L Graham Garrett T GT Fullam Anthony A Pillay Nischalan N Toretsky Jeffrey A JA Yoshida Akihiko A Shibata Tatsuhiro T Metzler Markus M Somers Gino R GR Scherer Stephen W SW Flanagan Adrienne M AM Campbell Peter J PJ Schiffman Joshua D JD Shago Mary M Alexandrov Ludmil B LB Wunder Jay S JS Andrulis Irene L IL Malkin David D Behjati Sam S Shlien Adam A
Science (New York, N.Y.) 20180801 6405
Sarcomas are cancers of the bone and soft tissue often defined by gene fusions. Ewing sarcoma involves fusions between <i>EWSR1</i>, a gene encoding an RNA binding protein, and E26 transformation-specific (ETS) transcription factors. We explored how and when <i>EWSR1-ETS</i> fusions arise by studying the whole genomes of Ewing sarcomas. In 52 of 124 (42%) of tumors, the fusion gene arises by a sudden burst of complex, loop-like rearrangements, a process called chromoplexy, rather than by simple ...[more]
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