Ontology highlight
ABSTRACT:
SUBMITTER: Alexander RA
PROVIDER: S-EPMC6176909 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Alexander Revu Ann RA Prager Gerald W GW Mihaly-Bison Judit J Uhrin Pavel P Sunzenauer Stefan S Binder Bernd R BR Schütz Gerhard J GJ Freissmuth Michael M Breuss Johannes M JM
Cardiovascular research 20120126 1
<h4>Aims</h4>Vascular endothelial growth factor (VEGF)-initiated angiogenesis requires coordinated proteolytic degradation of extracellular matrix provided by the urokinase plasminogen activator/urokinase receptor (uPA/uPAR) system and regulation of cell migration provided by integrin-matrix interaction. In this study, we investigated the mechanisms underlying the uPAR-dependent modulation of VEGF-induced endothelial migration.<h4>Methods and results</h4>We used flow cytometry to quantify integr ...[more]