Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki T
PROVIDER: S-EPMC6177207 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Suzuki Tatsuya T Okamoto Toru T Katoh Hiroshi H Sugiyama Yukari Y Kusakabe Shinji S Tokunaga Makoto M Hirano Junki J Miyata Yuka Y Fukuhara Takasuke T Ikawa Masahito M Satoh Takashi T Yoshio Sachiyo S Suzuki Ryosuke R Saijo Masayuki M Huang David C S DCS Kanto Tatsuya T Akira Shizuo S Matsuura Yoshiharu Y
PLoS pathogens 20180927 9
BCL2 family proteins including pro-survival proteins, BH3-only proteins and BAX/BAK proteins control mitochondria-mediated apoptosis to maintain cell homeostasis via the removal of damaged cells and pathogen-infected cells. In this study, we examined the roles of BCL2 proteins in the induction of apoptosis in cells upon infection with flaviviruses, such as Japanese encephalitis virus, Dengue virus and Zika virus. We showed that survival of the infected cells depends on BCLXL, a pro-survival BCL2 ...[more]