Ontology highlight
ABSTRACT:
SUBMITTER: Jin Y
PROVIDER: S-EPMC6177232 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Jin Yusung Y Kim Dokyoung D Roh Hajung H Kim Sojeong S Hussain Sazid S Kang Jinyoung J Pack Chan-Gi CG Kim Jun Ki JK Myung Seung-Jae SJ Ruoslahti Erkki E Sailor Michael J MJ Kim Song Cheol SC Joo Jinmyoung J
Advanced materials (Deerfield Beach, Fla.) 20180713 35
A nanoparticle system for systemic delivery of therapeutics is described, which incorporates a means of tracking the fate of the nanocarrier and its residual drug payload in vivo by photoluminescence (PL). Porous silicon nanoparticles (PSiNPs) containing the proapoptotic antimicrobial peptide payload, <sub>D</sub> [KLAKLAK]<sub>2</sub> , are monitored by measurement of the intrinsic PL intensity and the PL lifetime of the nanoparticles. The PL lifetime of the PSiNPs is on the order of microsecon ...[more]