Ontology highlight
ABSTRACT:
SUBMITTER: Miller MR
PROVIDER: S-EPMC6177234 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Cell reports 20180901 10
Ion channels control sperm navigation within the female reproductive tract and, thus, are critical for their ability to find and fertilize an egg. The flagellar calcium channel CatSper controls sperm hyperactivated motility and is dependent on an alkaline cytoplasmic pH. The latter is accomplished by either proton transporters or, in human sperm, via the voltage-gated proton channel Hv1. To provide concerted regulation, ion channels and their regulatory proteins must be compartmentalized. Here, ...[more]