Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke.
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ABSTRACT:
SUBMITTER: Pires PW
PROVIDER: S-EPMC6177258 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke.
Pires Paulo Wagner PW Earley Scott S
eLife 20180921
Hypoxia and ischemia are linked to oxidative stress, which can activate the oxidant-sensitive transient receptor potential ankyrin 1 (TRPA1) channel in cerebral artery endothelial cells, leading to vasodilation. We hypothesized that TRPA1 channels in endothelial cells are activated by hypoxia-derived reactive oxygen species, leading to cerebral artery dilation and reduced ischemic damage. Using isolated cerebral arteries expressing a Ca<sup>2+</sup> biosensor in endothelial cells, we show that 4 ...[more]
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