Ontology highlight
ABSTRACT:
SUBMITTER: Bharadwaj VN
PROVIDER: S-EPMC6177306 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Bharadwaj Vimala N VN Rowe Rachel K RK Harrison Jordan J Wu Chen C Anderson Trent R TR Lifshitz Jonathan J Adelson P David PD Kodibagkar Vikram D VD Stabenfeldt Sarah E SE
Nanomedicine : nanotechnology, biology, and medicine 20180619 7
Clinically, traumatic brain injury (TBI) results in complex heterogeneous pathology that cannot be recapitulated in single pre-clinical animal model. Therefore, we focused on evaluating utility of nanoparticle (NP)-based therapeutics following three diffuse-TBI models: mildclosed-head injury (mCHI), repetitive-mCHI and midline-fluid percussion injury (FPI). We hypothesized that NP accumulation after diffuse TBI correlates directly with blood-brainbarrier permeability. Mice received PEGylated-NP ...[more]