Ontology highlight
ABSTRACT:
SUBMITTER: Rodionova IA
PROVIDER: S-EPMC6177579 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Rodionova Irina A IA Goodacre Norman N Do Jimmy J Hosseinnia Ali A Babu Mohan M Uetz Peter P Saier Milton H MH
The Journal of biological chemistry 20180808 40
Folate derivatives are important cofactors for enzymes in several metabolic processes. Folate-related inhibition and resistance mechanisms in bacteria are potential targets for antimicrobial therapies and therefore a significant focus of current research. Here, we report that the activity of <i>Escherichia coli</i> poly-γ-glutamyl tetrahydrofolate/dihydrofolate synthase (FolC) is regulated by glutamate/glutamine-sensing uridylyltransferase (GlnD), THF-dependent tRNA modification enzyme (MnmE), a ...[more]