Ontology highlight
ABSTRACT:
SUBMITTER: Renzova T
PROVIDER: S-EPMC6178195 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Renzova Tereza T Bohaciakova Dasa D Esner Milan M Pospisilova Veronika V Barta Tomas T Hampl Ales A Cajanek Lukas L
Stem cell reports 20180906 4
Centrioles account for centrosomes and cilia formation. Recently, a link between centrosomal components and human developmental disorders has been established. However, the exact mechanisms how centrosome abnormalities influence embryogenesis and cell fate are not understood. PLK4-STIL module represents a key element of centrosome duplication cycle. We analyzed consequences of inactivation of the module for early events of embryogenesis in human embryonic stem cells (hESCs) and human induced plu ...[more]