Effects of Multiple Genetic Loci on Age at Onset in Frontotemporal Dementia.
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ABSTRACT:
SUBMITTER: Ferrari R
PROVIDER: S-EPMC6178215 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Effects of Multiple Genetic Loci on Age at Onset in Frontotemporal Dementia.
Ferrari Raffaele R Grassi Mario M Graziano Francesca F Palluzzi Fernando F Archetti Silvana S Bonomi Elisa E Bruni Amalia C AC Maletta Raffaele G RG Bernardi Livia L Cupidi Chiara C Colao Rosanna R Rainero Innocenzo I Rubino Elisa E Pinessi Lorenzo L Galimberti Daniela D Scarpini Elio E Serpente Maria M Nacmias Benedetta B Piaceri Irene I Bagnoli Silvia S Rossi Giacomina G Giaccone Giorgio G Tagliavini Fabrizio F Benussi Luisa L Binetti Giuliano G Ghidoni Roberta R Singleton Andrew A Hardy John J Momeni Parastoo P Padovani Alessandro A Borroni Barbara B
Journal of Alzheimer's disease : JAD 20170101 4
In frontotemporal dementia (FTD), age at disease onset (AAO) is unpredictable in both early and late-onset cases; AAO variability is found even in autosomal dominant FTD. The present study was aimed at identifying genetic modifiers modulating AAO in a large cohort of Italian FTD patients. We conducted an association analysis on 411 FTD patients, belonging to 7 Italian Centers, and for whom AAO was available. Population structure was evaluated by principal component analysis to infer continuous a ...[more]
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