Dataset Information

Exercise intervention alters HDL subclass distribution and function in obese women.

ABSTRACT:

Background

Obesity is associated with a change in high-density lipoprotein (HDL) function and subclass. Exercise training reduces cardiovascular risk in obese patients. We aimed to explore the effect of an exercise training stimulus on HDL functionality and subclass in obese women.

Methods

Thirty-two obese black South African women were randomly assigned to exercise (combined aerobic and resistance exercise) or control (no exercise) conditions for 12-weeks. Pre- and post-testing included venous blood sampling for analysis of lipid profile and HDL functionality, by measuring cellular cholesterol efflux capacity, reduction in endothelial vascular cell adhesion molecule (VCAM) expression (anti-inflammatory function), paraoxonase (PON) (antioxidative function) and platelet activating factor acetylhydrolase (PAF-AH) activities (anti-thrombotic function). PON-1 and PAF-AH expression were determined in serum and in isolated HDL using Western blotting. Levels of large, intermediate and small HDL subclasses were measured using the Lipoprint® system.

Results

Exercise training resulted in a decrease in body mass index (-?1.0?±?0.5% vs +?1.2?±?0.6%, p?=?0.010), PON activity (-?8.7?±?2.4% vs +?1.1?±?3.0%, p?=?0.021), PAF-AH serum expression (-?22.1?±?8.0% vs +?16.9?±?9.8, p?=?0.002), and the distribution of small HDL subclasses (-?10.1?±?5.4% vs +?15.7?±?6.6%, p?=?0.004) compared to controls. Exercise did not alter HDL cellular cholesterol efflux capacity and anti-inflammatory function.

Conclusions

These results demonstrate the potential for exercise training to modify HDL subclass distribution and HDL function in obese women.

Trial registration

Clinical trials number: PACTR201711002789113 .

SUBMITTER: Woudberg NJ

PROVIDER: S-EPMC6178267 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Publications

Exercise intervention alters HDL subclass distribution and function in obese women.

Woudberg Nicholas J NJ Mendham Amy E AE Katz Arieh A AA Goedecke Julia H JH Lecour Sandrine S

Lipids in health and disease 20181010 1

<h4>Background</h4>Obesity is associated with a change in high-density lipoprotein (HDL) function and subclass. Exercise training reduces cardiovascular risk in obese patients. We aimed to explore the effect of an exercise training stimulus on HDL functionality and subclass in obese women.<h4>Methods</h4>Thirty-two obese black South African women were randomly assigned to exercise (combined aerobic and resistance exercise) or control (no exercise) conditions for 12-weeks. Pre- and post-testing i ...[more]

PMID: 30301473

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Dataset Information

Exercise intervention alters HDL subclass distribution and function in obese women.

Background

Methods

Results

Conclusions

Trial registration

Publications

Exercise intervention alters HDL subclass distribution and function in obese women.

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