Ontology highlight
ABSTRACT:
SUBMITTER: Cerrato V
PROVIDER: S-EPMC6178385 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
PLoS biology 20180927 9
The morphological, molecular, and functional heterogeneity of astrocytes is under intense scrutiny, but how this diversity is ontogenetically achieved remains largely unknown. Here, by quantitative in vivo clonal analyses and proliferation studies, we demonstrate that the major cerebellar astrocyte types emerge according to an unprecedented and remarkably orderly developmental program comprising (i) a time-dependent decline in both clone size and progenitor multipotency, associated with clone al ...[more]