Ontology highlight
ABSTRACT:
SUBMITTER: Cortone G
PROVIDER: S-EPMC6179184 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Cortone Giuseppe G Zheng Ge G Pensieri Pasquale P Chiappetta Viviana V Tatè Rosarita R Malacaria Eva E Pichierri Pietro P Yu Hongtao H Pisani Francesca M FM
PLoS genetics 20181010 10
Establishment of sister chromatid cohesion is coupled to DNA replication, but the underlying molecular mechanisms are incompletely understood. DDX11 (also named ChlR1) is a super-family 2 Fe-S cluster-containing DNA helicase implicated in Warsaw breakage syndrome (WABS). Herein, we examined the role of DDX11 in cohesion establishment in human cells. We demonstrated that DDX11 interacts with Timeless, a component of the replication fork-protection complex, through a conserved peptide motif. The D ...[more]