Ontology highlight
ABSTRACT:
SUBMITTER: Aghajanian C
PROVIDER: S-EPMC6179372 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Aghajanian Carol C Filiaci Virginia V Dizon Don S DS Carlson Jay W JW Powell Matthew A MA Secord Angeles Alvarez AA Tewari Krishnansu S KS Bender David P DP O'Malley David M DM Stuckey Ashley A Gao JianJiong J Dao Fanny F Soslow Robert A RA Lankes Heather A HA Moore Kathleen K Levine Douglas A DA
Gynecologic oncology 20180524 2
<h4>Objective</h4>Paclitaxel and carboplatin (PC) is a standard initial therapy for advanced endometrial cancer. We evaluated the efficacy and tolerability of incorporating three novel agents into initial therapy.<h4>Methods</h4>In this randomized phase II trial, patients with chemotherapy-naïve stage III/IVA (with measurable disease) and stage IVB or recurrent (with or without measurable disease) endometrial cancer were randomly assigned to treatment with PC plus bevacizumab (Arm 1), PC plus te ...[more]