Ontology highlight
ABSTRACT:
SUBMITTER: Oyen D
PROVIDER: S-EPMC6179375 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Oyen David D Torres Jonathan L JL Cottrell Christopher A CA Richter King C C Wilson Ian A IA Ward Andrew B AB Ward Andrew B AB
Science advances 20181010 10
The circumsporozoite protein (CSP) on the surface of <i>Plasmodium falciparum</i> sporozoites is important for parasite development, motility, and host hepatocyte invasion. However, intrinsic disorder of the NANP repeat sequence in the central region of CSP has hindered its structural and functional characterization. Here, the cryo-electron microscopy structure at ~3.4-Å resolution of a recombinant shortened CSP construct with the variable domains (Fabs) of a highly protective monoclonal antibod ...[more]