Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A.
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ABSTRACT:
SUBMITTER: Burgess EJ
PROVIDER: S-EPMC6179936 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A.
Burgess Edward J EJ Hoyt Laura R LR Randall Matthew J MJ Mank Madeleine M MM Bivona Joseph J JJ Eisenhauer Philip L PL Botten Jason W JW Ballif Bryan A BA Lam Ying-Wai YW Wargo Matthew J MJ Boyson Jonathan E JE Ather Jennifer L JL Poynter Matthew E ME
Journal of immunology (Baltimore, Md. : 1950) 20180829 8
Studies comparing endogenous and recombinant serum amyloid A (SAA) have generated conflicting data on the proinflammatory function of these proteins. In exploring this discrepancy, we found that in contrast to commercially sourced recombinant human SAA1 (hSAA1) proteins produced in <i>Escherichia coli</i>, hSAA1 produced from eukaryotic cells did not promote proinflammatory cytokine production from human or mouse cells, induce Th17 differentiation, or stimulate TLR2. Proteomic analysis of <i>E. ...[more]
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2019-09-01 | GSE128598 | GEO
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