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Chronic Hepatitis B Infection Is Significantly Associated with Chronic Kidney Disease: a Population-based, Matched Case-control Study.


ABSTRACT:

Background

Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study investigated the association between chronic HBV infection and CKD in a nationwide multicenter study.

Methods

A total of 265,086 subjects who underwent health-check examinations in 33 hospitals from January 2015 to December 2015 were enrolled. HBV surface antigen (HBsAg) positive cases (n = 10,048), and age- and gender-matched HBsAg negative controls (n = 40,192) were identified. CKD was defined as a glomerular filtration rate (GFR) < 60 mL/min/1.73 m2 or proteinuria as at least grade 2+ of urine protein.

Results

HBsAg positive cases showed a significantly higher prevalence of GFR < 60 mL/min/1.73 m2 (3.3%), and proteinuria (18.9%) than that of the controls (2.6%, P < 0.001, and 14.1%, P < 0.001, respectively). In the multivariate analysis, HBsAg positivity was an independent factor associated with GFR < 60 mL/min/1.73 m2 along with age, blood levels of albumin, bilirubin, anemia, and hemoglobin A1c (HbA1c). Likewise, HBsAg positivity was an independent factor for proteinuria along with age, male, blood levels of bilirubin, protein, albumin, and HbA1c. A subgroup analysis showed that HBsAg positive men but not women had a significantly increased risk for GFR < 60 mL/min/1.73 m2.

Conclusion

Chronic HBV infection was significantly associated with a GFR < 60 mL/min/1.73 m2 and proteinuria (≥ 2+). Therefore, clinical concern about CKD in chronic HBV infected patients, especially in male, is warranted.

SUBMITTER: Kim SE 

PROVIDER: S-EPMC6179986 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Chronic Hepatitis B Infection Is Significantly Associated with Chronic Kidney Disease: a Population-based, Matched Case-control Study.

Kim Sung-Eun SE   Jang Eun Sun ES   Ki Moran M   Gwak Geum-Youn GY   Kim Kyung-Ah KA   Kim Gi-Ae GA   Kim Do Young DY   Kim Dong Joon DJ   Kim Man Woo MW   Kim Yun Soo YS   Kim Young Seok YS   Kim In Hee IH   Kim Chang Wook CW   Kim Ho Dong HD   Kim Hyung Joon HJ   Park Neung Hwa NH   Baik Soon Koo SK   Suh Jeong Ill JI   Song Byung-Cheol BC   Song Il Han IH   Yeon Jong Eun JE   Lee Byung Seok BS   Lee Youn Jae YJ   Jung Young Kul YK   Chung Woo Jin WJ   Cho Sung Bum SB   Cho Eun-Young EY   Cho Hyun Chin HC   Cheon Gab Jin GJ   Chae Hee Bok HB   Choi DaeHee D   Choi Sung-Kyu SK   Choi Hwa Young HY   Tak Won Young WY   Heo Jeong J   Jeong Sook-Hyang SH  

Journal of Korean medical science 20180912 42


<h4>Background</h4>Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study investigated the association between chronic HBV infection and CKD in a nationwide multicenter study.<h4>Methods</h4>A total of 265,086 subjects who underwent health-check examinations in 33 hospitals from January 2015 to December 2015 were enrolled. HBV surface antigen (HBsAg) positive  ...[more]

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