Low lymphocyte count and high monocyte count predicts poor prognosis of gastric cancer.

ABSTRACT: BACKGROUND:Existing data about the prognostic value of absolute count of blood cells in gastric cancer was limited. Thus, the present study aims to investigate the prognostic value of absolute count of white blood cell (WBC), neutrophil, lymphocyte, monocyte and platelet in gastric cancer patients. METHODS:From September 2008 to March 2015, 3243 patients treated with radical gastrectomy were enrolled in the present study. Clinicopathological characteristics were recorded. The prognostic value of blood test in gastric cancer patients were analyzed. RESULTS:There were 2538 male and 705 female. The median age was 58 years (range 20-90). The median follow-up time was 24.9 months (range 1-75). The 1-, 3- and 5-year overall survival rate was 88.9%, 65.8% and 57.2%, respectively. The optimal cut off value was 6.19?×?109/L for WBC (P?=?0.146), 4.19?×?109/L for neutrophil (P?=?0.004), 1.72?×?109/L for lymphocyte (P?=?0.000), 0.51?×?109/L for monocyte (P?=?0.019) and 260.0?×?109/L for platelet (P?=?0.002), respectively. Neutrophil, lymphocyte, monocyte and platelet were risk factors for the prognosis of gastric cancer (all P?

SUBMITTER: Feng F 

PROVIDER: S-EPMC6180580 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature