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Phytochemical study of Piliostigma thonningii, a medicinal plant grown in Nigeria.


ABSTRACT: Piliostigma thonningii (Schumach.) Milne-Redhead. (Leguminosae) is used for various medicinal purposes in African countries. Phytochemical investigation of P. thonningii yielded two compounds newly isolated from natural sources, 2?-methoxyclovan-9?-ol (1), and methyl-ent-3?-hydroxylabd-8(17)-en-15-oate (2), along with 14 known compounds (3-16). Compounds 1 and 4 (alepterolic acid) showed potential selectivity towards Trypanosoma brucei brucei with IC50 7.89 and 3.42 ?M, respectively. Compound 2 showed activity towards T. brucei and Leishmania donovani Amastigote with IC50 3.84 and 7.82 ?M, respectively. The structure activity relationship (SAR) of the isolated metabolites suggested that hydroxylation at C-2 enhances the antiprotozoal activity towards T. brucei in sesquiterpenes 1 and 3. Similarly hydroxylation at C-3 in labdane diterpenes elevates the antiprotozoal activity towards T. brucei.

SUBMITTER: Afolayan M 

PROVIDER: S-EPMC6181138 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Phytochemical study of <i>Piliostigma thonningii</i>, a medicinal plant grown in Nigeria.

Afolayan Michael M   Srivedavyasasri Radhakrishnan R   Asekun Olayinka T OT   Familoni Oluwole B OB   Orishadipe Abayomi A   Zulfiqar Fazila F   Ibrahim Mohamed A MA   Ross Samir A SA  

Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents 20180825 10


<i>Piliostigma thonningii</i> (Schumach.) Milne-Redhead. (Leguminosae) is used for various medicinal purposes in African countries. Phytochemical investigation of <i>P. thonningii</i> yielded two compounds newly isolated from natural sources, 2<i>β</i>-methoxyclovan-9<i>α</i>-ol (<b>1</b>), and methyl-<i>ent</i>-3<i>β</i>-hydroxylabd-8(17)-en-15-oate (<b>2</b>), along with 14 known compounds (<b>3</b>-<b>16</b>). Compounds <b>1</b> and <b>4</b> (alepterolic acid) showed potential selectivity tow  ...[more]

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