Ontology highlight
ABSTRACT:
SUBMITTER: Klughammer J
PROVIDER: S-EPMC6181207 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Klughammer Johanna J Kiesel Barbara B Roetzer Thomas T Fortelny Nikolaus N Nemc Amelie A Nenning Karl-Heinz KH Furtner Julia J Sheffield Nathan C NC Datlinger Paul P Peter Nadine N Nowosielski Martha M Augustin Marco M Mischkulnig Mario M Ströbel Thomas T Alpar Donat D Ergüner Bekir B Senekowitsch Martin M Moser Patrizia P Freyschlag Christian F CF Kerschbaumer Johannes J Thomé Claudius C Grams Astrid E AE Stockhammer Günther G Kitzwoegerer Melitta M Oberndorfer Stefan S Marhold Franz F Weis Serge S Trenkler Johannes J Buchroithner Johanna J Pichler Josef J Haybaeck Johannes J Krassnig Stefanie S Mahdy Ali Kariem K von Campe Gord G Payer Franz F Sherif Camillo C Preiser Julius J Hauser Thomas T Winkler Peter A PA Kleindienst Waltraud W Würtz Franz F Brandner-Kokalj Tanisa T Stultschnig Martin M Schweiger Stefan S Dieckmann Karin K Preusser Matthias M Langs Georg G Baumann Bernhard B Knosp Engelbert E Widhalm Georg G Marosi Christine C Hainfellner Johannes A JA Woehrer Adelheid A Bock Christoph C
Nature medicine 20180827 10
Glioblastoma is characterized by widespread genetic and transcriptional heterogeneity, yet little is known about the role of the epigenome in glioblastoma disease progression. Here, we present genome-scale maps of DNA methylation in matched primary and recurring glioblastoma tumors, using data from a highly annotated clinical cohort that was selected through a national patient registry. We demonstrate the feasibility of DNA methylation mapping in a large set of routinely collected FFPE samples, ...[more]