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Copper-Containing Catalytic Amyloids Promote Phosphoester Hydrolysis and Tandem Reactions.

ABSTRACT: Self-assembly of short de novo designed peptides gives rise to catalytic amyloids capable of facilitating multiple chemical transformations. We show that catalytic amyloids can efficiently hydrolyze paraoxon, a widely used, highly toxic organophosphate pesticide. Moreover, these robust and inexpensive metal-containing materials can be easily deposited on various surfaces producing catalytic flow devices. Finally, functional promiscuity of catalytic amyloids promotes tandem hydrolysis/oxidation reactions. High efficiency discovered in a very small library of peptides suggests an enormous potential for further improvement of catalytic properties both in terms of catalytic efficiency and substrate scope.

SUBMITTER: Lengyel Z

PROVIDER: S-EPMC6181230 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Copper-Containing Catalytic Amyloids Promote Phosphoester Hydrolysis and Tandem Reactions.

Lengyel Zsófia Z Rufo Caroline M CM Moroz Yurii S YS Makhlynets Olga V OV Korendovych Ivan V IV

ACS catalysis 20171122 1

Self-assembly of short de novo designed peptides gives rise to catalytic amyloids capable of facilitating multiple chemical transformations. We show that catalytic amyloids can efficiently hydrolyze paraoxon, a widely used, highly toxic organophosphate pesticide. Moreover, these robust and inexpensive metal-containing materials can be easily deposited on various surfaces producing catalytic flow devices. Finally, functional promiscuity of catalytic amyloids promotes tandem hydrolysis/oxidation r ...[more]

PMID: 30319881

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