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ABSTRACT: Background
To evaluate the effect of probiotic supplementation on functional constipation in children.Methods
We performed electronic searches in PubMed, Embase, and Cochrane Library without language restriction to identify relevant studies from the time of inception of these databases to March 2018. The relative risk or weighted mean difference was calculated to evaluate the treatment effect of probiotics using random-effects model.Results
We included 4 trials reporting data on 382 children with functional constipation. Overall, there were no significant differences in treatment success (P?=?.697), spontaneous bowel movements per week (P?=?.571), fecal soiling episodes per week (P?=?.642), straining at defecation (P?=?.408), use of lactulose (P?=?.238), use of laxatives (P?=?.190), fecal incontinence (P?=?.139), pain during defecation (P?=?.410), flatulence (P?=?.109), and adverse events (P?=?.979) between probiotics and placebo. Further, the use of probiotics was associated with lower frequency of glycerin enema use (weighted mean difference -2.40, P?=?.004) and abdominal pain (weighted mean difference -4.80, P?ConclusionThe findings of this study suggested that the use of probiotics was associated with significant improvement in glycerin enema use and abdominal pain but did not affect the treatment success and other function indices.
SUBMITTER: Jin L
PROVIDER: S-EPMC6181519 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Medicine 20180901 39
<h4>Background</h4>To evaluate the effect of probiotic supplementation on functional constipation in children.<h4>Methods</h4>We performed electronic searches in PubMed, Embase, and Cochrane Library without language restriction to identify relevant studies from the time of inception of these databases to March 2018. The relative risk or weighted mean difference was calculated to evaluate the treatment effect of probiotics using random-effects model.<h4>Results</h4>We included 4 trials reporting ...[more]