Ontology highlight
ABSTRACT:
SUBMITTER: Yuan F
PROVIDER: S-EPMC6181563 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Yuan Fang F Chen Xin X Fang Kai-Heng KH Wang Yuanyuan Y Lin Mingyan M Xu Shi-Bo SB Huo Hai-Qin HQ Xu Min M Ma Lixiang L Chen Yuejun Y He Shuijin S Liu Yan Y
eLife 20180925
Human GABAergic interneurons (GIN) are implicated in normal brain function and in numerous mental disorders. However, the generation of functional human GIN subtypes from human pluripotent stem cells (hPSCs) has not been established. By expressing LHX6, a transcriptional factor that is critical for GIN development, we induced hPSCs to form GINs, including somatostatin (SST, 29%) and parvalbumin (PV, 21%) neurons. Our RNAseq results also confirmed the alteration of GIN identity with the overexpre ...[more]