Ontology highlight
ABSTRACT:
SUBMITTER: Spinosa M
PROVIDER: S-EPMC6181641 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Spinosa Michael M Lu Guanyi G Su Gang G Bontha Sai Vineela SV Gehrau Ricardo R Salmon Morgan D MD Smith Joseph R JR Weiss Mark L ML Mas Valeria R VR Upchurch Gilbert R GR Sharma Ashish K AK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20180529
The formation of an abdominal aortic aneurysm (AAA) is characterized by inflammation, macrophage infiltration, and vascular remodeling. In this study, we tested the hypothesis that mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) immunomodulate aortic inflammation, to mitigate AAA formation via modulation of microRNA-147. An elastase-treatment model of AAA was used in male C57BL/6 wild-type (WT) mice. Administration of EVs in elastase-treated WT mice caused a significant atten ...[more]