Unknown

Dataset Information

0

Anodal transcranial direct current stimulation prevents methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity by modulating autophagy in an in vivo mouse model of Parkinson's disease.


ABSTRACT: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the accumulation of protein inclusions and the loss of dopaminergic neurons. Transcranial direct current stimulation (tDCS) is a non-invasive brain-stimulating technique that has demonstrated promising results in clinical studies of PD. Despite accumulating evidence indicating that tDCS exerts a protective effect, the mechanism underlying its activity remains unknown. In the present study, we first investigated the neuroprotective effect of tDCS in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model and then evaluated the effect of tDCS on the autophagy pathway. tDCS improved behavioral alterations, increased tyrosine hydroxylase protein levels and suppressed α-synuclein protein levels in MPTP-treated mice. MPTP-treated mice subjected to tDCS also had lower levels of autophagy-related proteins, such as microtubule-associated protein 1 light chain 3 and AMP-activated protein kinase, and higher levels of mechanistic target of rapamycin and p62. In addition, the protein levels of phosphoinositide 3-kinase and brain-derived neurotrophic factor were higher, and the levels of unc-51-like kinase 1 were lower in MPTP-treated mice subjected to tDCS. Our findings suggest that tDCS protected against MPTP-induced PD in a mouse model by modulating autophagy.

SUBMITTER: Lee SB 

PROVIDER: S-EPMC6181991 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4127494 | biostudies-literature
| S-EPMC3392900 | biostudies-literature
| S-EPMC3734004 | biostudies-literature
| S-EPMC9529090 | biostudies-literature
| S-EPMC156340 | biostudies-literature
2006-05-12 | GSE4788 | GEO
| S-EPMC6579075 | biostudies-literature
| S-EPMC3037617 | biostudies-literature
| S-EPMC1147429 | biostudies-other