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The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease.

ABSTRACT: Hydroxylation is a novel protein modification catalyzed by a family of oxygenases that depend on fundamental nutrients and metabolites for activity. Protein hydroxylases have been implicated in a variety of key cellular processes that play important roles in both normal homeostasis and pathogenesis. Here, in this review, we summarize the current literature on a highly conserved sub-family of oxygenases that catalyze protein histidyl hydroxylation. We discuss the evidence supporting the biochemical assignment of these emerging enzymes as ribosomal protein hydroxylases, and provide an overview of their role in immunology, bone development, and cancer.

SUBMITTER: Bundred JR

PROVIDER: S-EPMC6182338 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease.

Bundred James R JR Hendrix Eline E Coleman Mathew L ML

Cellular and molecular life sciences : CMLS 20180827 22

Hydroxylation is a novel protein modification catalyzed by a family of oxygenases that depend on fundamental nutrients and metabolites for activity. Protein hydroxylases have been implicated in a variety of key cellular processes that play important roles in both normal homeostasis and pathogenesis. Here, in this review, we summarize the current literature on a highly conserved sub-family of oxygenases that catalyze protein histidyl hydroxylation. We discuss the evidence supporting the biochemic ...[more]

PMID: 30151692

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