Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC6182773 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Wang Xiaolei X Krasnova Larissa L Wu Kevin Binchia KB Wu Wei-Shen WS Cheng Ting-Jen TJ Wong Chi-Huey CH
Bioorganic & medicinal chemistry letters 20180315 16
Described here is the asymmetric synthesis of iminosugar 2b, a Lipid II analog, designed to mimic the transition state of transglycosylation catalyzed by the bacterial transglycosylase. The high density of functional groups, together with a rich stereochemistry, represents an extraordinary challenge for chemical synthesis. The key 2,6-anti- stereochemistry of the iminosugar ring was established through an iridium-catalyzed asymmetric allylic amination. The developed synthetic route is suitable f ...[more]