Ontology highlight
ABSTRACT:
SUBMITTER: Madan M
PROVIDER: S-EPMC6183320 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Madan Madhu M Sikriwal Deepa D Sharma Gaurav G Shukla Nidhi N Mandyal Ashwani Kumar AK Kale Sachin S Gill Davinder D
Human vaccines & immunotherapeutics 20180711 9
To develop a safe and efficacious heat-stable rotavirus vaccine, new lyophilized formulations were developed using rotavirus serotypes constituting RotaTeq®. A series of formulation compositions, differing in buffering agents, bulking agents, cryoprotectants, amino acids and divalent cations, were screened for their ability to provide stability to rotavirus serotypes during lyophilization and when stored under elevated temperatures for extended periods. Lead formulations and lyophilization cycle ...[more]