Ontology highlight
ABSTRACT:
SUBMITTER: Abe H
PROVIDER: S-EPMC6185175 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Abe Hironori H Alavattam Kris G KG Kato Yasuko Y Castrillon Diego H DH Pang Qishen Q Andreassen Paul R PR Namekawa Satoshi H SH
Human molecular genetics 20180401 7
The continuity of life depends on mechanisms in the germline that ensure the integrity of the genome. The DNA damage response/checkpoint kinases ATM and ATR are essential signaling factors in the germline. However, it remains unknown how a downstream transducer, Checkpoint Kinase 1 (CHEK1 or CHK1), mediates signaling in the male germline. Here, we show that CHEK1 has distinct functions in both the mitotic and meiotic phases of the male germline in mice. In the mitotic phase, CHEK1 is required fo ...[more]