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Racial/ethnic variation in the prevalence of vaccine-related human papillomavirus genotypes.


ABSTRACT: Objective: There are currently three licensed human papillomavirus (HPV) vaccines that protect against cervical cancer. Here we compare the prevalence of bi-, quadri-, and nonavalent vaccine-related HPV genotypes in a multi-ethnic sample of non-Hispanic white, non-Hispanic black, Hispanic, and Asian women. Design: Patients in this analysis (n?=?419) represent a subset of women with a previous abnormal Pap test participating in a clinical trial. HPV genotyping was conducted using the Roche Linear Array. Prevalent HPV genotypes were grouped according to their inclusion in each of the vaccines: bivalent (16, 18), quadrivalent (16, 18, 6, 11), and nonavalent (16, 18, 31, 33, 45, 52, 58, 6, 11). Results: The prevalence of HPV genotypes covered by the bi-/quadrivalent vaccines was lowest among non-Hispanic black (15%) and Hispanic women (20%), compared to non-Hispanic white (38%) and Asian women (38%). Across all racial/ethnic groups, a large proportion of infections (38%-49%) were with genotypes included in the nonavalent vaccine. However, the prevalence of HPV genotypes not covered by any vaccine was significantly higher among non-Hispanic black (36%) and Hispanic women (42%), compared to non-Hispanic white (24%) and Asian women (16%) (p?

SUBMITTER: Montealegre JR 

PROVIDER: S-EPMC6185800 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Racial/ethnic variation in the prevalence of vaccine-related human papillomavirus genotypes.

Montealegre Jane R JR   Varier Indu I   Bracamontes Christina G CG   Dillon Laura M LM   Guillaud Martial M   Sikora Andrew G AG   Follen Michele M   Adler-Storthz Karen K   Scheurer Michael E ME  

Ethnicity & health 20170904 7


<b>Objective:</b> There are currently three licensed human papillomavirus (HPV) vaccines that protect against cervical cancer. Here we compare the prevalence of bi-, quadri-, and nonavalent vaccine-related HPV genotypes in a multi-ethnic sample of non-Hispanic white, non-Hispanic black, Hispanic, and Asian women. <b>Design:</b> Patients in this analysis (<i>n</i> = 419) represent a subset of women with a previous abnormal Pap test participating in a clinical trial. HPV genotyping was conducted u  ...[more]

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