Plasma contact factors as therapeutic targets.
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ABSTRACT:
SUBMITTER: Tillman BF
PROVIDER: S-EPMC6185818 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Plasma contact factors as therapeutic targets.
Tillman Benjamin F BF Gruber Andras A McCarty Owen J T OJT Gailani David D
Blood reviews 20180412 6
Direct oral anticoagulants (DOACs) are small molecule inhibitors of the coagulation proteases thrombin and factor Xa that demonstrate comparable efficacy to warfarin for several common indications, while causing less serious bleeding. However, because their targets are required for the normal host-response to bleeding (hemostasis), DOACs are associated with therapy-induced bleeding that limits their use in certain patient populations and clinical situations. The plasma contact factors (factor XI ...[more]
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